TABLE 3
Kinetic parameters for midazolam hydroxylation by human liver microsomes
K
m
V
max
CL
int
μ
M
nmol/min/mg protein
ml/min/mg protein
%
α-Hydroxylation
3.8
4.41
1.16
84.8
4-Hydroxylation
13.4
2.79
0.208
15.2