TABLE 5

Prediction of the increase in midazolam AUC by macrolides

			Predicted AUC Ratio
	Pretreatment	Midazolam	k_deg (min^-1)			Reported
			0.0005	0.00033	AUC Ratio (mean ± S.D.)	Reference
Erythromycin	500 mg t.i.d. for 6 days	i.v.	1.7	2.0	2.2 ± 0.6	Olkkola et al., 1993
	500 mg t.i.d. for 6 days	p.o.	3.0	3.7	4.4 ± 2.4	Olkkola et al., 1993
	500 mg t.i.d. for 5 days	p.o.	2.9	3.6	3.8 ± 2.4	Zimmermann et al., 1996
Clarithromycin	500 mg b.i.d. for 7 days	i.v.	2.0	2.2	2.7 ± 1.0	Gorski et al., 1998
	500 mg b.i.d. for 7 days	p.o.	2.5	2.9	7.0 ± 4.2	Gorski et al., 1998
	250 mg b.i.d. for 5 days	p.o.	2.1	2.2	3.6 ± 1.7	Yeates et al., 1996
Azithromycin	500 mg o.d. for 3 days	p.o.	1.0	1.0	1.2 ± 0.7	Olkkola et al., 1993
	500 mg o.d. for 3 days	p.o.	1.0	1.0	1.3 ± 0.9	Gorski et al., 1998