Comparison of responses of CYP3A4-luc reporter in transgenic mice to activation of murine and human PXRs in vitro
Low | Moderate | High | |
|---|---|---|---|
| CYP3A4-luc transgenic mice | Rifampicin | Nifedipine | Clotrimazole |
| Phenobarbital | PCN | ||
| Pregnenolone | Dexamethasone | ||
| mPXRa | Rifampicin | Dexamethasone | PCN |
| Phenobarbital | Pregnenolone | ||
| Clotrimazole | |||
| hPXRa | PCN | Pregnenolone | Rifampicin |
| Dexamethasone | Phenobarbital | Clotrimazole | |
|
|
|
Nifedipine
|
|