Measured kinetic parameters (sP450 and cP450).
Substrate/Enzyme | Km | Vmax | ||||
|---|---|---|---|---|---|---|
|
sP450
|
cP450
|
sP450
|
cP450
| |||
| μM | nmol/min/nmol protein | |||||
| Phenacetin/1A2 | 25 ± 4.2 | 65 ± 8.5 | 1.4 ± 0.1 | 1.6 ± 0.1 | ||
| Diclofenac/2C9 | 2 ± 0.1 | ± 0.3 | 14 ± 0.1 | 9 ± 0.3 | ||
| Mephenytoin/2C19 | 20 ± 3.1 | 19 ± 2.6 | 13 ± 0.5 | 17 ± 1.0 | ||
| Bufuralol/2D6 | 9 ± 0.8 | 7 ± 0.6 | 12 ± 0.4 | 9 ± 0.3 | ||
|
Midazolam/3A4
|
2.5 ± 0.6
|
2.4 ± 0.2
|
2.4 ± 0.2
|
5 ± 0.3
| ||