TABLE 5

Measured vs. literature IC₅₀ values.

Enzyme/Inhibitor	IC₅₀ μM					Reference
Enzyme/Inhibitor		sP450	cP450	Literature		Reference
1A2 α-Napthoflavone			0.02	Moody et al., 1999
			0.05	Sai et al., 2000
			0.082	Yin et al., 2000
	0.04 ± 0.008	0.05 ± 0.006	0.12	Bu et al., 2001
2C9 Sulphaphenazole			1	Dierks et al., 2001
			0.56	Bu et al., 2001
			1.3	Yin et al., 2000
	0.26 ± 0.08	0.44 ± 0.07	0.5	Eagling et al., 1998
2C19 Tranylcypromine			9	Dierks et al., 2001
			44	Bu et al., 2001
	8.9 ± 2	11 ± 1
2D6 Quinidine			<0.1	Dierks et al., 2001
			0.2	Bu et al., 2001
			0.18	Yin et al., 2000
	0.02 ± 0.006	0.03 ± 0.004	0.4	Sai et al., 2000
3A4 Ketoconazole			0.03	Sai et al., 2000
			0.17	Moody et al., 1999
			0.1	Dierks et al., 2001
	0.008 ± 0.002	0.015 ± 0.002	0.09	Yin et al., 2000