Estimates of the metabolic rate in various in vitro systems
Candidate System | Assumptions | CLh | CLh (Summed)a | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
DMS
|
MA
|
A
|
SEL
| |||||||
| l/h | ||||||||||
| Recombinant expressed enzymes | Relative content (BD Gentest) | 95.7 | 128.2 | na | na | 223.8 | ||||
| Liver microsomes | 45 mg microsomal protein/g liver | 30 | 61.2 | na | na | 91.2 | ||||
| Hepatocytes | 120 million hepatocytes/g liver | 1.38 | 3.56 | 0.25 | 16.1 | 5.2 | ||||
|
Liver slices
|
200 mg total protein/g liver
|
na
|
na
|
na
|
na
|
36.5
| ||||
na, not available
↵ a DMS + MA + A