Kinetic parameters for the in vitro effect of various CYP3A4 substrates
on testosterone in human lymphoblast-expressed CYP3A4, generated by multisite
kinetic model approach (mean ± S.E.) The kinetic parameters were
determined using kinetic model (n = 25-30) defined by equation 4,
β (Kp from SES) = 2. Vmax is
equivalent to 2Kp[E]t, in which [E]t
is the total enzyme concentration (Segel,
1975).