TABLE 1

Apparent permeability coefficients (× 106 cm·s-1) of verapamil based on appearance in the receptor chamber and disappearance from the donor chamber Studies were conducted with 20 μM verapamil in the presence and absence of 20 μM midazolam, 50 μM ketoconazole, or 20 μM PSC833 in side-by-side diffusion chambers across stripped rat jejunum. Values were calculated according to eqs. 1 and 2, and data represent the mean ± S.D. of n = 6-9 determinations.

Condition
m to s
s to m
Appearance
    Control 11.20±3.39a 28.49±7.52a
    Midazolam 17.75±2.66a,b 32.91±7.91a
    Ketoconazole 25.39±2.64b 29.44±4.27
    PSC833 10.95±1.86a 24.43±4.62a
Disappearance
    Control 104.53±32.57 98.66±19.13
    Midazolam 91.94±9.48 92.47±22.75
    Ketoconazole 90.26±19.38 99.29±9.07
    PSC833
99.28±15.78
117.38±25.74

  • ↵ a Statistically significant difference between m to s and s to m permeability (p < 0.002)

  • ↵ b Statistically significant increase in permeability when compared to control (p < 0.05)