The mol% of verapamil and metabolite associated with tissue segments (1.78 cm2) after 180 min from 20 μM verapamil transport studies across rat jejunal tissue in the presence and absence of 20 μM midazolam, 50 μM ketoconazole, or 20 μM PSC833 Data represent the mean ± S.D. of n = 6-9 determinations
m to s | s to m | |||||
|---|---|---|---|---|---|---|
|
Verapamil
|
Metabolite
|
Verapamil
|
Metabolite
| |||
| Control | 11.42±2.58 | 1.36±0.51 | 10.29±1.25 | 0.91±0.29 | ||
| Midazolam | 13.59±1.67 | 0.24±0.05a | 10.43±2.55 | 0.10±0.03a | ||
| Ketoconazole | 9.63±1.23 | 0.01±0.01a | 10.87±1.02 | 0.02±0.01a | ||
|
PSC833
|
13.11±1.43
|
1.31±0.22
|
9.92±2.34
|
0.75±0.19
| ||
↵ a Significantly different from respective m to s or s to m control