Inhibitory effect of YM90K on organic anion uptake by hOATs and on organic cation uptake by hOCTs
Substrate | Percentage of Control Uptake at 300 μM YM90Ka | IC50 | Ki | |
|---|---|---|---|---|
| μM | ||||
| hOAT1 | PAH | 2.3 ± 0.1*** | 3.8 | 5.8c |
| hOAT2 | PGF2α | 63.6 ± 3.3*** | >300 | ND |
| hOAT3 | ES | 10.8 ± 0.0*** | 4.4 | 3.4b |
| hOAT4 | ES | 77.0 ± 0.8*** | >300 | ND |
| hOCT1 | TEA | 89.6 ± 5.5 | >300 | ND |
| hOCT2 | TEA | 95.4 ± 2.5 | >300 | ND |