TABLE 3

Inhibition of estradiol-3-glucronidation (UGT1A1) or zidovudine (AZT) glucuronidation by structurally diverse compounds in human liver microsomes Experiments were performed according to the previously described methodology (Court et al., 2003). HMF and valproic acid concentrations were taken to the limits of solubility. Data are means of triplicate incubations of three separate experiments for each compound. Stimulation of estradiol 3-glucuronidation increased with increasing AZT concentration to a maximal 174% of control activity at the highest AZT concentration tested (3 mM).