Homology models built for CYP2C9 and CYP2C5
Homology Models | I.D. | RMSD 1 vs. CYP2C9 | RMSD 2 vs. CYP2C5 | Ramachandran (%)a |
|---|---|---|---|---|
| CYP2C9 | ||||
| 2D alignment to CYP2C5 | ||||
| CYP2C9_2D_1 | 2.19 | 0.26 | 85.9 | |
| CYP2C9_2D_2 | 2.19 | 0.19 | 84.9 | |
| CYP2C9_2D_3 | 2.18 | 0.19 | 85.6 | |
| CYP2C9_2D_4 | 2.20 | 0.19 | 86.1 | |
| CYP2C9_2D_5 | 2.23 | 0.22 | 85.6 | |
| 3D alignment to CYP2C5 and BM3 | ||||
| CYP2C9_3D:A_1 | 2.24 | 0.61 | 83.1 | |
| CYP2C9_3D:A_2 | 2.23 | 0.69 | 83.4 | |
| CYP2C9_3D:A_3 | 2.23 | 0.78 | 83.9 | |
| CYP2C9_3D:A_4 | 2.23 | 0.78 | 83.9 | |
| CYP2C9_3D:A_5 | 2.24 | 0.77 | 83.6 | |
| 3D alignment to all crystal templates | ||||
| CYP2C9_3D:B_1 | 2.23 | 0.86 | 80.6 | |
| CYP2C9_3D:B_2 | 2.26 | 0.84 | 80.4 | |
| CYP2C9_3D:B_3 | 2.23 | 0.64 | 81.1 | |
| CYP2C9_3D:B_4 | 2.23 | 0.68 | 81.6 | |
| CYP2C9_3D:B_5 | 2.24 | 0.59 | 80.4 | |
| CYP2C5 | ||||
| 2D alignment to CYP2C9 | ||||
| CYP2C5_2D_1 | 0.34 | 2.18 | 91.6 | |
| CYP2C5_2D_2 | 0.35 | 2.17 | 92.1 | |
| CYP2C5_2D_3 | 0.35 | 2.19 | 92.3 | |
| CYP2C5_2D_4 | 0.36 | 2.17 | 93.1 | |
| CYP2C5_2D_5 | 0.36 | 2.17 | 91.6 | |
| 3D alignment to CYP2C9 and BM3 | ||||
| CYP2C5_3D:A_1 | 0.50 | 2.13 | 89.6 | |
| CYP2C5_3D:A_2 | 0.50 | 2.12 | 91.3 | |
| CYP2C5_3D:A_3 | 0.57 | 2.13 | 89.9 | |
| CYP2C5_3D:A_4 | 0.64 | 2.14 | 90.8 | |
| CYP2C5_3D:A_5 | 0.53 | 2.13 | 90.3 | |
| 3D alignment to all crystal templates | ||||
| CYP2C5_3D:B_1 | 2.94 | 3.61 | 84 | |
| CYP2C5_3D:B_2 | 2.93 | 3.60 | 85.9 | |
| CYP2C5_3D:B_3 | 2.57 | 3.29 | 86.2 | |
| CYP2C5_3D:B_4 | 2.95 | 3.64 | 87.4 | |
|
| CYP2C5_3D:B_5 | 3.08 | 3.66 | 85.4 |
↵ a Percentage of residues with psi and phi conformation in the “most favored regions” of the Ramachandran plot