Concentration of radioactivity (nanocuries per gram) in tissues of SD and SH male rats at 0.33 and 2 h after a single intravenous dose (10 mg/kg) of [3H]DE-3 and [3H]DE-4.
Mean tissue radioactivity concentrations were calculated by averaging 1) tissue concentrations measured at different sectioning levels and/or 2) tissue concentrations measured from replicate cryosections obtained from the same sectioning level; n values range from a minimum of 3 to a maximum of 30.
Tissue | [3H]DE-3 | [3H]DE-4 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.33 h | 2 h | 0.33 h | 2 h | |||||||||||
| SD | SH | SD | SH | SD | SH | SD | SH | |||||||
| Brain | ||||||||||||||
| Caudate putamen | 3100 | 1170 | 726 | 202 | 814 | 398 | 271 | — | ||||||
| Cerebellum | 2520 | 685 | 537 | 205 | 864 | 287 | 296 | — | ||||||
| Cerebrum | 3500 | 1050 | 664 | 261 | 1070 | 287 | 347 | — | ||||||
| Medulla oblongata | 2230 | 688 | 490 | 163 | 766 | 281 | 269 | — | ||||||
| Olfactory bulb | 2760 | 901 | 587 | ND | 826 | 265 | 306 | — | ||||||
| Pituitary | 6130 | 1620 | 1370 | 640 | 2330 | 680 | 759 | 202 | ||||||
| Spinal cord | 2320 | 427 | 496 | 147 | 871 | 198 | 302 | — | ||||||
| Glands | ||||||||||||||
| Adrenal | 3570 | 987 | 1060 | 405 | 1400 | 565 | 649 | 121 | ||||||
| Buccal | 5420 | 1470 | 1540 | 542 | 2220 | 863 | 1040 | 203 | ||||||
| Harderian | 10,500 | 1580 | 798 | 3470 | 2930 | 530 | 1890 | 148 | ||||||
| Pancreas | 3440 | 592 | 1300 | 243 | 1930 | 532 | 760 | 173 | ||||||
| Salivary | 5390 | 1620 | 2060 | 296 | 1970 | 759 | 861 | 240 | ||||||
| Spleen | 4020 | 1040 | 1150 | 410 | 1630 | 456 | 630 | 124 | ||||||
| Thymus | 2730 | 730 | 872 | 293 | 1280 | 414 | 535 | 104 | ||||||
| Thyroid | 2710 | 1730 | 967 | 502 | 1120 | 755 | 428 | 117 | ||||||
| Other tissues | ||||||||||||||
| Adipose, white | — | — | — | — | — | — | — | — | ||||||
| Bone marrow | 2790 | 648 | 677 | 374 | 1610 | 295 | 521 | 103 | ||||||
| Heart | 1950 | 525 | 518 | 192 | 1280 | 544 | 563 | 131 | ||||||
| Hepatic blood | 1100 | 175 | 351 | — | 1020 | 264 | 352 | — | ||||||
| Kidney cortex | 5030 | 1490 | 1600 | 733 | 2070 | 848 | 991 | 214 | ||||||
| Kidney medulla | 17,200 | 4020 | 2710 | 1780 | 5650 | 2890 | 3250 | 497 | ||||||
| Liver | 2970 | 858 | 1290 | 479 | 2000 | 802 | 843 | 183 | ||||||
| Lung | 3480 | 478 | 587 | 219 | 1750 | 458 | 724 | 90 | ||||||
| Lymph node | 2810 | 1050 | 873 | 456 | ND | 797 | ND | 129 | ||||||
| Muscle | 1780 | 496 | 459 | 206 | 1050 | 338 | 357 | 86 | ||||||
| Myocardial blood | 877 | 201 | 241 | — | 790 | 264 | 263 | — | ||||||
| Parodontium | 9920 | 2920 | 6330 | 4550 | 3900 | 516 | 3270 | 872 | ||||||
| Testis | 1440 | 498 | 1100 | 292 | 644 | 216 | 528 | 96 | ||||||
—, below lower quantification limit of 72 nCi/g; ND, tissue concentration not determined.