Parameter | Pharmacological Dose | |||
---|---|---|---|---|
LC-MS/MS Analysisa | AMS Analysis | Microdose (AMS Analysis) | ||
AUC0-t (ng or ng Eq · h/ml)b | 2181 | 2846 | 2725 | |
AUC0-inf (ng or ng Eq · h/ml) | 2442 | 3113 | 3085 | |
% AUC extrapolated | 10.5 | 8.3 | 12 | |
Cmax (ng or ng Eq/ml) | 502 | 659 | 635 | |
Tmax (h) | 0.5 | 0.5 | 0.38 | |
AUC0-t ratio at 1 mg/kg (parent levels/total 14C levels) | 0.77 | NA | ||
Cmax ratio at 1 mg/kg (parent levels/total 14C levels) | 0.76 |
| NA |
NA, not applicable.
↵ a These parameters were obtained in a group of dogs that were dosed with radiolabel in parallel to the dogs dosed for the AMS study. The 1 mg/kg oral data presented in Table 1 are from a separate study in which dogs were dosed with unlabeled compound. Parent levels of Compound A were determined by LC-MS/MS analysis and total 14C levels were determined by AMS analysis
↵ b The AUC0-t interval was from 0 to 80 h