Comparison of the indirect and direct method calculating the gut (EI) and liver (EH) extraction ratio of verapamil in rabbits and dogs Portal vein blood flow rates of 56.0 and 23.0 ml/min/kg were used as QH in rabbits and dogs.
Rabbits | Dogs | |||||
|---|---|---|---|---|---|---|
| Indirect | Direct | Indirect | Direct | |||
| Gut extraction ratio (EI) | ≈ 0 | 0.79 | ≈ 0 | ≈ 0 | ||
| Hepatic extraction ratio (EH) | >1 | 0.92 | > 1 | 0.78 | ||
| Bioavailability (BA) (%) | 1.65 | 41.9 | ||||