Inhibition of EE 3-O-sulfation by DCNP and quercetin in the presence of human cytosol and cDNA-expressed SULTs IC50 (μM) values for DCNP and quercetin at a final concentration of 3 nM EE. Values are presented as the parameter estimate ± S.E. (see eq. 2).
Enzyme Source | DCNP | Quercetin |
|---|---|---|
| SULT1A1*1 | 0.063 ± 0.007 | N.D. |
| SULT1E1 | 20 ± 2.3 | 0.6 ± 0.04 |
| SULT1A3 | 12.4 ± 1.8 | 7 ± 0.5 |
| Liver cytosol | 30 ± 3.2 | 0.5 ± 0.06 |
| Ileum cytosol | 15.6 ± 1.2 | 0.4 ± 0.08 |
N.D., not determined.