Doses of CLB and valproate, minimum plasma concentrations of CLB, NCLB, and valproate, and NCLB/CLB plasma metabolic ratios (mean ± S.D. (median) or [range]) in epileptic children 3.5 to 18.9 years old, treated with clobazam and valproate as comedications
CYP2C19*1/*1 (n = 18) | CYP2C19*1/*2 (n = 4) | p | |
|---|---|---|---|
| CLB (mg/kg/day) | 0.582 ± 0.183 | 0.495 ± 0.057 | |
| (0.556) | (0.469) | 0.372 | |
| [0.333-1.07] | [0.463-0.580] | ||
| CLB (mg/l:mg/kg) | 0.423 ± 0.375 | 0.376 ± 0.142 | |
| (0.313) | (0.395) | 0.832 | |
| [0.079-1.73] | [0.203-0.510] | ||
| NCLB (mg/l:mg/kg) | 1.28 ± 0.926 | 2.35 ± 1.24 | |
| (1.01) | (2.01) | 0.067 | |
| [0.386-3.88] | [1.24-4.13] | ||
| NCLB/CLB | 3.44 ± 1.51 | 6.18 ± 1.48 | |
| (3.22) | (6.07) | 0.012* | |
| [1.37-6.86] | [4.48-8.09] | ||
| Valproate (mg/kg/day) | 28.6 ± 7.9 | 24.6 ± 3.0 | |
| (29.6) | (24.2) | 0.136 | |
| [10.0-42.0] | [21.9-28.1] | ||
| Valproate (mg/l:mg/kg) | 3.23 ± 1.83 | 2.49 ± 0.41 | |
| (2.81) | (2.63) | 0.419 | |
|
| [1.02-9.32] | [1.89-2.81] |
|