TABLE 9

Unbound fractions of literature compound in chimpanzee and human plasma or serum.

Compound
Unbound Fraction (%)
Chimpanzee
Human
L-692,429a 6.0 6.6
L-695,256b 77 74
L-749,345c,d 1.2 2.9
Ceftriaxonec
3.5
3.2

  • ↵ a Leung et al. (1996) (determined by ultrafiltration in plasma at 1 μg/ml).

  • ↵ b Sundelof et al. (1996) (determined by ultrafiltration in plasma).

  • ↵ c Sundelof et al. (1997) (determined by ultrafiltration in serum).

  • ↵ d Also known as MK-0826/Ertapenem.