TABLE 1

Pharmacokinetic parameters of VPA after administration of VPA (25 mg/kg p.o.) with carbapenems (20 mg/kg i.v.) or saline to monkeys

Each value represents the mean ± S.D. of three monkeys.

Group
Tmax
Cmax
AUC0-6 h
MRT
CL
h μg/ml μg · h/ml h ml/h
Control (VPA + Saline) 0.7 ± 0.3 39.9 ± 9.8 160 ± 11 2.51 ± 0.49 157 ± 10
PAPM (VPA + PAPM) 1.0 ± 0.9 37.8 ± 14.7 93 ± 50* 1.40 ± 0.34* 374 ± 291
MEPM (VPA + MEPM) 1.0 ± 0.9 40.8 ± 2.9 98 ± 22* 1.46 ± 0.33 265 ± 64
S-4661 (VPA + S-4661)
0.7 ± 0.3
50.9 ± 16.1
118 ± 24
1.58 ± 0.34
218 ± 40

  • ↵* p < 0.05 (Dunnet's t test) vs control (VPA + Saline).