Pharmacokinetic parameters of VPA and VPA-G in plasma after administration of VPA with saline, S-4661, or PAPM to rats (30 mg/kg i.v.)
Each value represents the mean ± S.D. of six or three rats.
Administration | VPA | VPA-G AUC0-2h | ||||
|---|---|---|---|---|---|---|
| AUC0-2h | CL | t1/2 | ||||
| μg · h/ml | ml/h/kg | h | μg Eq of VPA · h/ml | |||
| VPA + Saline | 31.2 ± 4.1 | 947 ± 143 | 2.5 ± 1.8 | 4.7 ± 0.7 | ||
| VPA + S-4661 | 26.0 ± 2.9 | 1124 ± 100 | 0.7 ± 0.1 | 4.4 ± 0.6 | ||
| VPA + PAPM | 23.2 ± 2.0* | 1256 ± 101* | 0.6 ± 0.2 | 5.7 ± 0.8 | ||
↵* p < 0.05 (Student's t test) vs VPA + Saline.