TABLE 5

Pharmacokinetic parameters of VPA and VPA-G in plasma after administration of VPA-G with saline, S-4661, or PAPM to rats (6.87 mg Eq of VPA/kg, i.v.)

Each value represents the mean ± S.D. of three rats.

Administration	VPA-G AUC_0-2h	VPA AUC_0-2h
	μg Eq of VPA · h/ml	μg · h/ml
VPA-G + Saline	2.89 ± 0.32	1.88 ± 0.32
VPA-G + S-4661	2.59 ± 0.45	0.23 ± 0.05^*
VPA-G + PAPM	2.16 ± 0.24^*	0.19 ± 0.06^*

↵* p < 0.05 (Student's t test) vs VPA-G + Saline.