CL12 | CL21 | CL10 | CL20 | ||
---|---|---|---|---|---|
ml/h/kg | |||||
Control | 318 | 615 | 627 | 1960 | |
With S-4661 | 454 | 101 | 680 | 2582 | |
Control | 480 | 738 | 656 | 1941 | |
With PAPM | 793 | 113 | 489 | 3125 |
CL12, metabolic clearance of VPA to VPA-G; CL21, hydrolytic clearance of VPA-G to VPA; CL10, metabolic clearance except for glucuronidation; CL20, elimination clearance.