Excretion (Percentage of Dose) | |||
---|---|---|---|
Total Radioactivity | VPA-G | ||
Control | |||
Urine | |||
0-30 min | 28.09 ± 10.78 | 21.66 ± 10.06 | |
30-60 min | 19.49 ± 11.26 | 14.07 ± 9.34 | |
60-90 min | 7.65 ± 4.81 | 4.16 ± 3.42 | |
90-120 min | 3.77 ± 1.47 | 1.35 ± 0.99 | |
Total | 59.00 ± 27.85 | 41.24 ± 23.32 | |
Bile | |||
0-30 min | 15.18 ± 19.83 | 13.17 ± 16.98 | |
30-60 min | 9.10 ± 7.45 | 7.38 ± 5.75 | |
60-90 min | 2.26 ± 1.71 | 1.67 ± 1.25 | |
90-120 min | 0.82 ± 0.20 | 0.51 ± 0.16 | |
Total | 27.36 ± 28.44 | 22.73 ± 23.44 | |
Total | |||
0-30 min | 43.27 ± 9.07 | 34.82 ± 8.30 | |
30-60 min | 28.59 ± 4.03 | 21.46 ± 3.59 | |
60-90 min | 9.91 ± 3.59 | 5.83 ± 2.48 | |
90-120 min | 4.59 ± 1.37 | 1.86 ± 0.93 | |
Total | 86.36 ± 0.90 | 63.97 ± 4.12 | |
With S-4661 | |||
Urine | |||
0-30 min | 28.49 ± 16.69 | 23.06 ± 14.75 | |
30-60 min | 10.75 ± 3.70 | 6.80 ± 2.97 | |
60-90 min | 3.77 ± 1.06 | 1.70 ± 0.84 | |
90-120 min | 1.62 ± 0.94 | 0.62 ± 0.64 | |
Total | 44.63 ± 21.75 | 32.18 ± 18.66 | |
Bile | |||
0-30 min | 30.43 ± 15.02 | 26.96 ± 12.99 | |
30-60 min | 13.33 ± 7.50 | 10.76 ± 6.54 | |
60-90 min | 3.17 ± 2.56 | 2.29 ± 2.09 | |
90-120 min | 0.87 ± 0.69 | 0.56 ± 0.51 | |
Total | 47.81 ± 21.65 | 40.57 ± 18.14 | |
Total | |||
0-30 min | 58.92 ± 11.15 | 50.02 ± 9.51 | |
30-60 min | 24.09 ± 6.04 | 17.56 ± 5.76 | |
60-90 min | 6.94 ± 2.35 | 3.99 ± 1.99 | |
90-120 min | 2.49 ± 0.94 | 1.18 ± 0.62 | |
Total | 92.44 ± 2.27 | 72.75 ± 1.36 |