TABLE 7

Urinary and biliary excretion of total radioactivity and VPA-G after administration of VPA with and without S-4661 to rats (30 mg/kg i.v.)

Each value represents the mean ± S.D. of three rats.

Excretion (Percentage of Dose)
Total Radioactivity
VPA-G
Control
Urine
0-30 min 28.09 ± 10.78 21.66 ± 10.06
30-60 min 19.49 ± 11.26 14.07 ± 9.34
60-90 min 7.65 ± 4.81 4.16 ± 3.42
90-120 min 3.77 ± 1.47 1.35 ± 0.99
Total 59.00 ± 27.85 41.24 ± 23.32
Bile
0-30 min 15.18 ± 19.83 13.17 ± 16.98
30-60 min 9.10 ± 7.45 7.38 ± 5.75
60-90 min 2.26 ± 1.71 1.67 ± 1.25
90-120 min 0.82 ± 0.20 0.51 ± 0.16
Total 27.36 ± 28.44 22.73 ± 23.44
Total
0-30 min 43.27 ± 9.07 34.82 ± 8.30
30-60 min 28.59 ± 4.03 21.46 ± 3.59
60-90 min 9.91 ± 3.59 5.83 ± 2.48
90-120 min 4.59 ± 1.37 1.86 ± 0.93
Total 86.36 ± 0.90 63.97 ± 4.12
With S-4661
Urine
0-30 min 28.49 ± 16.69 23.06 ± 14.75
30-60 min 10.75 ± 3.70 6.80 ± 2.97
60-90 min 3.77 ± 1.06 1.70 ± 0.84
90-120 min 1.62 ± 0.94 0.62 ± 0.64
Total 44.63 ± 21.75 32.18 ± 18.66
Bile
0-30 min 30.43 ± 15.02 26.96 ± 12.99
30-60 min 13.33 ± 7.50 10.76 ± 6.54
60-90 min 3.17 ± 2.56 2.29 ± 2.09
90-120 min 0.87 ± 0.69 0.56 ± 0.51
Total 47.81 ± 21.65 40.57 ± 18.14
Total
0-30 min 58.92 ± 11.15 50.02 ± 9.51
30-60 min 24.09 ± 6.04 17.56 ± 5.76
60-90 min 6.94 ± 2.35 3.99 ± 1.99
90-120 min 2.49 ± 0.94 1.18 ± 0.62
Total
92.44 ± 2.27
72.75 ± 1.36