TABLE 8

Urinary and biliary excretion of total radioactivity and VPA-G after administration of VPA-G with and without S-4661 to rats (6.83 mg/kg i.v.)

Each value represents the mean ± S.D. of three rats.

Excretion (Percentage of Dose)
Total Radioactivity
VPA-G
Control
Urine
0-30 min 49.24 ± 1.84 39.89 ± 1.98
30-60 min 5.35 ± 0.36 2.56 ± 0.29
60-90 min 1.99 ± 0.49 0.36 ± 0.22
90-120 min 1.04 ± 0.14 0.14 ± 0.06
Total 57.62 ± 2.17 42.94 ± 2.19
Bile
0-30 min 28.03 ± 0.59 22.20 ± 1.06
30-60 min 1.87 ± 0.05 0.95 ± 0.20
60-90 min 0.52 ± 0.04 0.21 ± 0.06
90-120 min 0.23 ± 0.03 0.07 ± 0.03
Total 30.66 ± 0.68 23.43 ± 1.30
Total
0-30 min 77.27 ± 1.28 62.09 ± 2.29
30-60 min 7.22 ± 0.37 3.51 ± 0.47
60-90 min 2.51 ± 0.46 0.57 ± 0.17
90-120 min 1.28 ± 0.15 0.20 ± 0.05
Total 88.27 ± 1.53 66.37 ± 2.52
With S-4661
Urine
0-30 min 43.99 ± 6.22 21.27 ± 17.36
30-60 min 12.49 ± 6.01 6.96 ± 6.31
60-90 min 1.99 ± 0.36 0.72 ± 0.27
90-120 min 2.16 ± 2.50 1.10 ± 1.55
Total 60.64 ± 10.50 30.04 ± 24.01
Bile
0-30 min 29.66 ± 11.98 23.70 ± 10.20
30-60 min 3.22 ± 1.14 1.96 ± 0.96
60-90 min 0.79 ± 0.37 0.45 ± 0.29
90-120 min 0.26 ± 0.24 0.15 ± 0.17
Total 33.93 ± 13.43 26.26 ± 11.49
Total
0-30 min 73.65 ± 7.34 44.97 ± 10.21
30-60 min 15.71 ± 5.15 8.91 ± 5.57
60-90 min 2.78 ± 0.42 1.17 ± 0.19
90-120 min 2.42 ± 2.35 1.25 ± 1.44
Total
94.56 ± 2.93
56.30 ± 15.49