Comparison of tacrolimus model-independent (and dose-corrected) pharmacokinetic parameters at the time of measurement of gastric emptying (n = 50) and between recipients with normal gastric emptying (n = 26) and patients with delayed gastric emptying (n = 24)
Data are expressed as mean ± S.D. Differences between patients with normal and delayed gastric emptying were statistically evaluated by Student's t test or Wilcoxon rank test. A p value < 0.05 was considered statistically significant.
Pharmacokinetic Parameter | All Patients (n = 50) | Normal Gastric Emptying (n = 26) | Delayed Gastric Emptying (n = 24) | p Value |
|---|---|---|---|---|
| AUC0-4 h (ng · h/ml) | 59.0 ± 20.7 | 59.9 ± 18.7 | 57.9 ± 23 | 0.48 |
| AUC0-12 h (ng ·h/ml) | 145.0 ± 46.7 | 142.4 ± 39.3 | 147.7 ± 54.1 | 0.92 |
| AUC0-12 h (ng · h/ml/mg) | 53.7 ± 26.5 | 52.9 ± 25.4 | 54.4 ± 28.2 | 0.87 |
| C0 (ng/ml) | 9.4 ± 3.7 | 8.8 ± 3 | 10 ± 4.3 | 0.40 |
| C0 (ng/ml/mg) | 3.5 ± 2.0 | 3.3 ± 1.9 | 3.8 ± 2.1 | 0.46 |
| Cmax (ng/ml) | 19.1 ± 7.1 | 20.0 ± 6.5 | 18.1 ± 7.8 | 0.24 |
| Cmax (ng/ml/mg) | 6.9 ± 3.5 | 7.3 ± 3.5 | 6.4 ± 3.4 | 0.25 |
| tmax (hr) | 1.76 ± 0.9 | 1.48 ± 0.68 | 2.00 ± 1.00 | 0.04 |
| Clearance (l/h/kg) | 0.32 ± 0.17 | 0.31 ± 0.13 | 0.33 ± 0.20 | 0.84 |
| Daily dose (mg/day) | 6.3 ± 4.0 | 6.0 ± 3.4 | 6.5 ± 4.7 | 0.85 |
| Weight-corrected daily dose (mg/kg/day) | 0.08 ± 0.05 | 0.07 ± 0.03 | 0.09 ± 0.06 | 0.80 |