Treatment and Daily Dosagesa | No. of Rats | Rat Weight | Blood Plasmab | Liver Wet Weight | Liver per Body Weight | ||
---|---|---|---|---|---|---|---|
ALT | AST | ||||||
g | IU | g | % | ||||
Control (olive oil), 2.5 ml/kg (1 day) | 5 | 252 ± 18 | 58 ± 11 | 109 ± 19 | 11.9 ± 2.2 | 4.7 ± 0.6 | |
Arochlor 1254, 0.5 g/kg (1 day) | 5 | 255 ± 6 | 47 ± 15 | 149 ± 24* | 18.5 ± 1.9** | 7.3 ± 0.7** | |
Control (5% aqueous sucrose), 2.5 ml/kg (3 days) | 5 | 260 ± 9 | 57 ± 11 | 107 ± 7 | 11.9 ± 1.0 | 4.6 ± 0.4 | |
4-Methylcatechol | |||||||
100 mg (0.81 mmol)/kg (3 days) | 5 | 258 ± 20 | 61 ± 5 | 110 ± 26 | 12.3 ± 1.9 | 4.8 ± 0.4 | |
150 mg (1.21 mmol)/kg (3 days) | 5 | 269 ± 11 | 70 ± 11 | 85 ± 6 | 11.8 ± 0.8 | 4.4 ± 0.2 | |
4-Nitrocatechol | |||||||
100 mg (0.64 mmol)/kg (3 days) | 5 | 260 ± 14 | 59 ± 9 | 90 ± 8 | 11.1 ± 1.2 | 4.3 ± 0.5 | |
200 mg (1.29 mmol)/kg (3 days) | 5 | 284 ± 25 | 60 ± 7 | 90 ± 19 | 12.9 ± 1.7 | 4.6 ± 0.4 | |
Control (olive oil), 3 ml/kg (3 days) | 5 | 279 ± 20 | 63 ± 14 | 92 ± 12 | 12.7 ± 1.5 | 4.5 ± 0.3 | |
2,3-Dihydroxynaphthalene, 300 mg (1.87 mmol)/kg (3 days) | 5 | 284 ± 15 | 72 ± 4 | 122 ± 8** | 13.3 ± 1.5 | 4.7 ± 0.4 | |
Control (olive oil), 3 ml/kg (3 days) | 5 | 293 ± 4 | 73 ± 10 | 75 ± 21 | 12.3 ± 0.9 | 4.2 ± 0.3 | |
Entacapone, 200 mg (0.66 mmol)/kg (3 days) | 5 | 283 ± 8 | 75 ± 5 | 88 ± 8 | 12.3 ± 1.5 | 4.7 ± 0.8 | |
Tolcapone, 200 mg (0.73 mmol)/kg (3 days) | 5 | 276 ± 10 | 76 ± 8 | 87 ± 13 | 11.8 ± 1.4 | 4.3 ± 0.5 |