RAF estimates (nmol of P450/mg protein) for CYP3A4, CYP3A5, and CYP2C19 using two different liver sources
Marker | Liver Source | |||
|---|---|---|---|---|
| Human Liver Banka | BD Gentest Human Liver Pool | |||
| CYP3A4 | Quinidine 3-hydroxylation | 0.46 ± 0.33 | 0.71 | |
| CYP3A5 | Alprazolam 1′ -hydroxylation | 0.11 ± 0.10 | 0.089 | |
| CYP2C19 | Mephenytoin 4′-hydroxylation | 0.0042 ± 0.0037 | 0.011 | |
↵ a Values represent mean ± S.D. of RAF estimates obtained in 12 livers.