Metabolite | CYP3A4 | CYP3A5 | 3A5/3A4 Ratio | |
---|---|---|---|---|
ml/min/nmol | ||||
6β-OH TST | 0.104 | 0.066 | 0.63 | |
N-Desmethyl ERM | 0.099 | 0.041 | 0.41 | |
1′-OH MDZ | 1.84 | 5.62 | 3.05 | |
4-OH MDZ | 0.16 | 0.14 | 0.88 | |
3-OH FLZ | 0.11 | 0.039 | 0.35 | |
Desmethyl FLZ | 0.015 | 0.003 | 0.20 | |
CBZ 10,11-epoxide | 0.010 | 0.009 | 0.90 | |
3-MM | 0.015 | 0.016* | 1.07 | |
TFN alcohol | 1.72 | 0.763 | 0.44 | |
MEGX | 0.051 | 0.069 | 1.35 |
↵* Estimated from a regression of the “linear” velocity-substrate concentration plot.