SNP Perfusion Time | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
P450s | 0.5-h Washout Period | 1-h Washout Period | |||||||||
0 h | 0.5 h | 2.5 h | 0 h | 1 h | 2 h | ||||||
% control | |||||||||||
CYP2C11 | 92 ± 15 | 88 ± 7 | 98 ± 10 | 91 ± 9 | 110 ± 13 | 68 ± 5a,b | |||||
CYP3A2 | 86 ± 8 | 84 ± 11 | 75 ± 15 | 90 ± 13 | 90 ± 4 | 88 ± 18 | |||||
CYP2E1 | 92 ± 10 | 84 ± 6 | 98 ± 5 | 91 ± 8 | 110 ± 6 | 100 ± 10 | |||||
CYP1A1/2 | 86 ± 10 | 94 ± 7 | 110 ± 7 | 89 ± 1 | 110 ± 8 | 110 ± 2 |