TABLE 1

NNAL-N-Gluc and NNAL-O-Gluc formation in microsomes prepared from the livers of 42 individual subjects


Liver Specimen #

Smoking Categorya

NNAL-N-Gluc

NNAL-O-Gluc

NNAL-N-Gluc/NNAL-O-Gluc
pmol[zmd]min-1 · mg protein-1 pmol · min-1 · mg protein-1
592 NS 4.01 2.01 2.00
2116 NS 4.10 4.80 0.86
2784 NS 4.29 5.31 0.81
2175 NS 4.92 5.49 0.90
1811 NS 5.99 3.82 1.57
1696 NS 6.30 4.93 1.28
2167 NS 6.30 6.23 1.01
161 NS 6.37 6.40 1.00
236 NS 7.69 6.42 1.20
3803 NS 8.74 13.44 0.65
1312 NS 8.93 6.38 1.40
2644 NS 10.05 7.16 1.40
289 NS 10.26 6.74 1.52
3333 NS 11.09 4.51 2.46
511 NS 11.17 5.62 1.99
386 NS 11.62 6.02 1.93
2312 NS 12.28 6.59 1.86
4423 NS 12.56 6.63 1.89
348 NS 13.13 6.67 1.97
3303 NS 13.44 4.19 3.21
365 NS 13.74 9.41 1.46
3889 NS 15.33 12.64 1.21
3790 NS 15.42 6.08 2.53
2505 NS 15.55 7.06 2.20
3054 NS 15.91 8.27 1.92
2843 NS 16.64 7.49 2.22
2050 NS 22.25 9.58 2.32
1010 NS 23.32 12.36 1.89
3474 MS 0.48 0.35 1.37
563 MS 0.59 0.27 2.19
1049 MS 2.53 2.03 1.25
3376 MS 4.88 2.28 2.14
1378 MS 7.38 6.26 1.18
1950 MS 7.81 3.21 2.43
972 MS 8.62 5.23 1.65
1680 MS 9.92 4.87 2.04
4290 MS 12.92 6.83 1.89
2887 MS 13.68 5.82 2.35
4178 MS 17.03 12.25 1.39
415 MS 21.84 8.66 2.52
505 HS 5.39 7.93 0.68
2635
HS
17.27
10.27
1.68
  • a NS, never smokers; MS, moderate smokers; HS, heavy smokers.