TABLE 2

Mean NNAL-N-Gluc and NNAL-O-Gluc formation in microsomes prepared from the livers of 42 individual subjects stratified by smoking


Smoking Category

NNAL-N-Gluc

NNAL-O-Gluc

NNAL-N-Gluc/NNAL-O-Gluc
pmol · min-1 · mg protein-1 pmol · min-1 · mg protein-1
Never-smokers 11.1 ± 5.1a 6.9 ± 2.6 1.7 ± 0.6
Moderate-smokers 9.0 ± 6.6 4.8 ± 3.5 1.9 ± 0.5
Heavy-smokers 11.3 ± 8.4 9.1 ± 1.7 1.2 ± 0.7
Moderate-heavy smokers 9.3 ± 6.5 5.5 ± 3.6 1.8 ± 0.6
Total cohort
10.5 ± 5.6
6.4 ± 3.0
1.7 ± 0.6
  • a Mean ± S.D.