TABLE 1

Tissue distribution of cinacalcet-derived radioactivity after a single oral dose to Sprague-Dawley rats

	Male							Female
Tissue	mg Eq/g			mg Eq · h/g AUC_{(48 h)}	T/P AUC^a Ratio	mg Eq/g			mg Eq · h/g AUC_{(48 h)}	T/P AUC^a Ratio
	4 h	48 h		mg Eq · h/g AUC_{(48 h)}	T/P AUC^a Ratio		4 h	48 h	mg Eq · h/g AUC_{(48 h)}	T/P AUC^a Ratio
Adrenal gland	2.82	2.08	116	1.25	2.15	2.40	117	1.35
Blood	1.69	BLQ	35	0.37	0.52	BLQ	29	0.33
Bone marrow	2.25	1.81	120	1.30	1.27	1.65	90	1.04
Cecum^b	3.72	0.59	129	1.40	1.27	1.16	95	1.03
Harderian gland	6.73	6.60	576	6.19	3.49	7.69	492	5.66
Kidney	3.74	1.79	130	1.41	2.65	1.68	113	1.31
Large intestines^b	1.56	1.07	83	0.90	0.48	0.00	59	0.65
Liver	7.82	2.47	225	2.43	4.71	2.46	203	2.35
Lung	3.57	1.06	84	0.91	2.91	BLQ	45	0.52
Pancreas	6.79	1.15	135	1.46	3.76	0.55	105	1.21
Plasma	3.38	0.89	93	1.00	1.74	0.88	87	1.00
Skin	1.07	1.16	61	0.66	BLQ	0.74	NA	NA
Small intestines^b	5.95	1.29	150	1.63	4.19	0.68	112	1.22
Spleen	3.39	1.42	98	1.06	2.27	1.17	79	0.91
Stomach^b	6.12	1.09	107	1.16	1.68	0.57	61	0.67
Thyroid	1.68	1.41	78	0.84	0.52	1.27	58	0.67

BLQ, below limit of quantitation; NA, not applicable.
↵ a T/P, tissue to plasma ratio of 0- to 48-h AUC, which was calculated by the linear trapezoidal method.
↵ b AUC_{(48 h)} for the contents of cecum, large intestines, small intestines, and stomach in male and female rats were in the range of 1140 to 1510 μg Eq · h/g.