Pharmacokinetics of cinacalcet and total plasma radioactivity in monkeys and humans after a single oral dose
Values are mean ± S.D.
Dose | Tmax | Cmax | t1/2 | AUC0-t | |
|---|---|---|---|---|---|
| mg/kg | h | ng/ml | h | ng · h/ml | |
| Plasma cinacalcet | |||||
| Monkey (3) | 10 | 4.67 ± 1.15 | 23.9 ± 10.8 | 6.59 ± 3.20 | 209.8 ± 143.4 |
| Monkey (3) | 100 | 13.3 ± 9.24 | 101.3 ± 29.5 | 13.0 ± 2.42 | 2611.1 ± 701.3 |
| Human (5) | ∼1a | 3.00 ± 0 | 10.6 ± 2.78 | 34.3 ± 8.61 | 116 ± 29.7 |
| Human (5)b | ∼1a | 2.90 ± 0.89 | 12.2 ± 5.55 | 41.0 ± 16.54 | 129 ± 52.4 |
| h | μg Eq/g or ml | h | μg Eq · h/g | ||
| Total plasma radioactivity | |||||
| Monkey (3) | 10 | 4.67 ± 1.15 | 8.65 ± 1.94 | 65.5 ± 19.9 | 135 ± 20.2 |
| Monkey (3) | 100 | 9.33 ± 2.31 | 49.5 ± 4.19 | 65.2 ± 1.93 | 1442 ± 470 |
| Human (5) | ∼1a | 2.80 ± 0.44 | 2.85 ± 0.22 | 15.7 ± 2.45 | 54.0 ± 14.87c |
| Human (5)b | ∼1a | 2.60 ± 0.54 | 3.03 ± 0.33 | 15.8 ± 3.13 | 45.3 ± 10.48c |