Excretion of radioactivity after a single oral dose of [14C-CF3]cinacalcet
Values are mean ± S.D.
Species | Sex (N) | Dose | Study Days | Percentage of Radioactive Dose Excreted | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Urine | Feces | Bile | Totala | |||||||
| mg/kg | ||||||||||
| Mouse | Male (6) | 10 | 4 | 50.6 ± 6.76 | 37.2 ± 3.19 | NA | 87.8 ± 4.00 | |||
| Mouse | Female (6) | 10 | 4 | 69.0 ± 7.12 | 27.3 ± 4.55 | NA | 96.3 ± 12.1 | |||
| Rat | Male (4) | 10 | 4 | 46.5 ± 3.00 | 44.5 ± 4.40 | NA | 91.2 ± 2.20 | |||
| Monkey | Male (3) | 10 | 5 | 56.6 ± 7.97 | 19.7 ± 7.68 | NA | 80.4 ± 12.0 | |||
| Monkey | Male (3) | 100 | 5 | 51.1 ± 6.29 | 29.4 ± 5.02 | NA | 86.4 ± 2.19 | |||
| Monkey | Male (3) | 100 | 5 | 35.9 ± 3.99 | 19.1 ± 4.29 | 38.4 ± 3.81 | 95.8 ± 1.05 | |||
| Humanb | Male (5) | ∼1 | 8 | 83.2 ± 5.13 | 13.1 ± 2.37 | NA | 96.3 ± 3.43 | |||
| Humanc | Male (5) | ∼1 | 8 | 80.3 ± 5.00 | 16.9 ± 2.50 | NA | 97.4 ± 3.62 | |||