Extracellular levels of S 16020 and metabolites in human hepatocyte cultures as percentage of total radioactivity after various treatments
These results represent the mean from two different hepatocyte cultures (FT179 and FT193). The incubation periods are presented in hours.
UT | S16020 | RIF | TCDD | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 h | 8 h | 24 h | 4 h | 8 h | 24 h | 4 h | 8 h | 24 h | 4 h | 8 h | 24 h | |||||||||
| H1 | 7.1 | 7.6 | 7.8 | 13 | 16 | 20 | 7.5 | 7.8 | 14 | 13 | 14 | 17 | ||||||||
| H2 | 5.4 | 5.7 | 4.2 | 4.2 | 3.6 | 3.9 | 3.9 | 4.6 | 4.6 | 3.5 | 3.5 | 3.4 | ||||||||
| H6 | 1.3 | 2.2 | 6.0 | 0.6 | 1.8 | 2.6 | 5.7 | |||||||||||||
| H7 | 2.9 | 4.6 | 6.2 | 0.6 | 3.6 | 4.9 | 7.2 | |||||||||||||
| H8 | 11 | 8.1 | 5.1 | 7.7 | 5.4 | 5.2 | 9.2 | 6.8 | 3.6 | 6.9 | 5.5 | 4.0 | ||||||||
| H13 | 3.8 | 4.7 | 3.8 | 1.8 | 4.0 | 6.3 | 4.5 | |||||||||||||
| H18 | 1.5 | 2.5 | 5.1 | 2.1 | 0.5 | 1.8 | 1.7 | 4.6 | ||||||||||||
| H20 | 3.1 | 5.2 | 12 | 0.9 | 3.7 | 6.4 | 11 | |||||||||||||
| H26 | 24 | 37 | 47 | 5.3 | 6.6 | 4.0 | 21 | 34 | 34 | 5.3 | 5.4 | 4.7 | ||||||||
| S16018 | 1.6 | 12 | 5.6 | 13 | 5.6 | |||||||||||||||
| H30 | 0.8 | 4.5 | 9.8 | 7.2 | 6.3 | 6.3 | 9.0 | 10 | ||||||||||||
| H33 | 2.2 | 3.8 | 2.9 | 5.4 | 4.9 | 1.6 | 2.7 | 3.8 | ||||||||||||
| S31919 | 7.8 | 13 | 18 | 1.9 | 1.9 | 1.0 | 7.9 | 12 | 10 | 2.0 | 1.8 | 2.0 | ||||||||
| S16020 | 16 | 9.7 | 2.0 | 2.6 | 0.4 | 13 | 7.6 | 2.4 | 0.9 | |||||||||||
| S19505 | 25 | 17 | 5.8 | 16 | 6.7 |
| 26 | 19 | 3.4 | 14 | 7.0 |
| ||||||||
UT, untreated hepatocytes; S 16020, S16020-induced hepatocytes; RIF, rifampicin-induced hepatocytes; TCDD, dioxin-induced hepatocytes.