Pharmacokinetic parameters obtained for ketoconazole in the monkey after either intravenous or intraduodenal administration All data are expressed as mean ± standard deviation for n = 3 monkeys per dose.
Parameter | Intravenous | Intraduodenal | ||||
|---|---|---|---|---|---|---|
| Portal | Systemic | |||||
| Dose (mg/kg) | 0.98 ± 0.07 | 10.2 ± 0.1 | ||||
| Cmax (ng/ml) | 961 ± 20 | 13,853 ± 2828 | 1259 ± 628 | |||
| Tmax (min) | -a | 8.33 ± 5.77 | 30 ± 0 | |||
| AUC (min · μg/ml) | 78.4 ± 9.8 | 407 ± 106 | 116 ± 45 | |||
| DNAUC (min · kg/l) | 80.1 ± 7.1 | 28.5 ± 5.8 | 11.4 ± 4.4 | |||
| CL (ml/min/kg) | 12.5 ± 1.2 | - | ||||
| Vdss (l/kg) | 0.661 ± 0.119 | - | ||||
| Half-life (min) | 50.6 ± 6.5 | - | ||||
| MRT (min) | 53.3 ± 12.0 | - | ||||
| Absorption (%)b | - | 55.2 ± 11.2 | ||||
| Hepatic extraction (%)b | - | 61.1 ± 6.9 | ||||
| Bioavailability (%) | - |
| 22.0 ± 8.5 |
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