Enantioselectivity in VER metabolism by CYP3A4, CYP3A5, and CYP3A7
CYP | Metabolite | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| NV | D617 | M1 | M2 | M3 | M4 | ||||||
| 3A4 | S | R | S | S | R | R | |||||
| 3A5 | R | R | S | R | S | S | |||||
| 3A7 |
S
|
S
|
S
|
S
|
R
|
R
| |||||
R and S represent more extensively metabolized VER enantiomer.