Mean excretion of radioactivity in urine and feces after intravenous administration of [14C]UK-294,315 to rat and dog, and oral administration to rat, dog, and human
Percent Dose | |||||
|---|---|---|---|---|---|
| Urine | Feces | Total | |||
| Rat (n = 4) | |||||
| 0.5 mg/kg i.v. (±S.D.) | 5.3 (0.5) | 89.5 (6.5) | 95.5a (6.1) | ||
| 4.0 mg/kg p.o. (±S.D.) | 3.2 (1.5) | 98.3 (5.3) | 101.9b (4.5) | ||
| Dog (n = 2) | |||||
| 0.5 mg/kg i.v. (range) | 6.6 (4.9-8.3) | 88.2 (88.1-88.3) | 94.8 (93.0-96.6) | ||
| 4.0 mg/kg p.o. (range) | 5.2 (4.0-6.3) | 87.7 (86.5-88.9) | 92.9 (92.8-92.9) | ||
| Human (n = 3) | |||||
| 0.29 mg/kgc p.o. (±S.D.) | 4.3 (0.2) | 97.5 (5.9) | 101.8 (5.9) | ||