Variable | R isomer | S isomer | S/R ratio |
---|---|---|---|
Maternal values | |||
Fluoxetine | |||
AUC (μg · h/l) | 126.1 ± 37.6 | 202.1 ± 46.6* | 1.65 ± 0.33** |
CL (ml/min · kg) | 50.7 ± 12.4 | 30.7 ± 3.8* | 0.62 ± 0.10** |
Vdss (liter/kg) | 9.3 ± 1.3 | 6.3 ± 1.1* | 0.68 ± 0.11** |
t1/2β (h) | 6.6 ± 2.5 | 6.7 ± 0.7 | 1.14 ± 0.48 |
Norfluoxetine | |||
AUC (μg · h/l) | 135.2 ± 50.5 | 131.7 ± 65.9 | 0.94 ± 0.22 |
t1/2β (h) | 28.2 ± 18.6 | 18.4 ± 7.8 | 0.72 ± 0.15 |
AUCFNX/AUCFX | 1.10 ± 0.39 | 0.63 ± 0.23 | 0.59 ± 0.18** |
Fetal values | |||
Fluoxetine | |||
AUC (μg · h/l) | 69.8 ± 18.0 | 124.6 ± 54.8* | 1.73 ± 0.29** |
t1/2β (h) | 10.8 ± 1.3*** | 9.3 ± 0.3*** | 0.87 ± 0.09 |
F/MAUC | 0.58 ± 0.19** | 0.60 ± 0.15** | 1.38 ± 0.40 |
Norfluoxetine | |||
AUC (μg · h/l) | 69.7 ± 27.3 | 93.4 ± 57.9 | 1.25 ± 0.29 |
AUCNFX/AUCFX | 0.98 ± 0.15 | 0.72 ± 0.18 | 0.72 ± 0.08** |
t1/2β (h) | 32.5 ± 3.6 | 21.6 ± 2.9 | 0.66 ± 0.05** |
F/MAUC | 0.53 ± 0.13 | 0.76 ± 0.33 | 1.39 ± 0.40 |