TABLE 3

Accuracy of bufuralol clearance predictions for extensive (EM) and poor (PM) metabolizers

Referencea
V/K
EM/ PM
CLint
[HLM]
Time
fu-mic
CL (no binding)b
CL (all fu)c
Percentage Accuracyd
ml/min/mg ml/min/kg mg/ml min ml/min/kg ml/min/kg
1 0.0007 AVG 0.6802 2 60 0.375 0.66 0.33 5.37
2 0.0723 EM 68.349 1 5 0.534 15.5 10.87 76.5
3 0.0012 EM 1.1512 1 30 0.534 1.09 0.39 4.47
4 0.0040 EM 3.7544 0.2 40 0.902 3.16 0.75 8.47
5 0.0077 EM 7.2622 0.15 40 0.968 5.33 1.30 14.8
6 0.0563 EM 53.239 0.1 15 1.000 14.54 6.62 75.3
3 0.0001 PM 0.0508 1 30 0.534 0.05 0.02 0.50
4 0.0002 PM 0.2022 0.2 40 0.902 0.20 0.04 1.19
5 0.0010 PM 0.9009 0.15 40 0.968 0.86 0.17 4.90
6 0.0194 PM 18.290 0.10 15 1.000 9.55 2.91 83.1
7 0.0163 AVG 15.403 0.4 3 0.752 8.69 3.19 51.9
7
0.0053
AVG
5.0081
0.4
120
0.752
4.00
1.16
18.9

  • ↵ a 1, Minder et al. (1983); 2, Prueksaritanont et al. (1995); 3, Yamazaki et al. (1994); 4, Dayer et al. (1984); 5, Dayer et al., 1987; 6, Nakamura et al., 2002; 7, this article

  • ↵ b Plasma and microsomal protein binding ignored

  • ↵ c Plasma and microsomal protein binding incorporated into calculation

  • ↵ d Reported in vivo CL = 8.8 ml/min/kg (EM) and 3.5 ml/min/kg (PM) (Dayer et al., 1985). AVG CL (EM + PM/2) = 6.15