The parameters GI50, TGI, and LC50 obtained for 6-MP in the NCI anticancer screen Parameters below or above the highest or lowest drug concentration used are listed as <0.01 or >100, respectively. All values are given in micromolar concentration (μM).
Cell Line | Tissue Type | GI50 | TGI | LC50 | Cell Line | Tissue Type | GI50 | TGI | LC50 |
|---|---|---|---|---|---|---|---|---|---|
| CCRF-CEM | Leukemia | 1.26 | >100 | >100 | LOX IMVI | Melanoma | 0.38 | >100 | >100 |
| HL-60(TB) | Leukemia | 2.44 | >100 | >100 | MALME-3M | Melanoma | 3.66 | >100 | >100 |
| K-562 | Leukemia | 0.35 | >100 | >100 | M14 | Melanoma | 0.67 | >100 | >100 |
| MOLT-4 | Leukemia | 1.61 | >100 | >100 | SK-MEL-2 | Melanoma | 5.97 | >100 | >100 |
| RPMI-8226 | Leukemia | 1.76 | >100 | >100 | SK-MEL-28 | Melanoma | >100 | >100 | >100 |
| SR | Leukemia | 1.24 | >100 | >100 | SK-MEL-5 | Melanoma | 8.36 | >100 | >100 |
| UACC-257 | Melanoma | 14.4 | >100 | >100 | |||||
| A549/ATCC | NSCL | 30.1 | >100 | >100 | UACC-62 | Melanoma | 1.76 | >100 | >100 |
| HOP-62 | NSCL | 1.75 | >100 | >100 | |||||
| HOP-92 | NSCL | 2.94 | >100 | >100 | IGR-OV1 | Ovarian | 9.48 | >100 | >100 |
| NCI-H23 | NSCL | 3.89 | >100 | >100 | OVCAR-3 | Ovarian | 0.86 | >100 | >100 |
| NCI-H322M | NSCL | 9.46 | >100 | >100 | OVCAR-4 | Ovarian | 8.05 | >100 | >100 |
| NCI-H460 | NSCL | 5.53 | >100 | >100 | OVCAR-5 | Ovarian | 8.63 | >100 | >100 |
| NCI-H522 | NSCL | 1.62 | >100 | >100 | OVCAR-8 | Ovarian | 2.54 | >100 | >100 |
| SK-OV-3 | Ovarian | 1.03 | >100 | >100 | |||||
| COLO 205 | Colon | 4.94 | >100 | >100 | |||||
| HCT-116 | Colon | 2.37 | >100 | >100 | 786-0 | Renal | 2.03 | >100 | >100 |
| HCT-15 | Colon | 4.57 | >100 | >100 | ACHN | Renal | 6.27 | >100 | >100 |
| HT29 | Colon | 4.02 | >100 | >100 | CAKI-1 | Renal | 3.21 | >100 | >100 |
| KM12 | Colon | 7.57 | >100 | >100 | SN12C | Renal | 23.8 | >100 | >100 |
| SW-620 | Colon | 6.38 | >100 | >100 | TK-10 | Renal | 1.94 | >100 | >100 |
| UO-31 | Renal | 6.85 | >100 | >100 | |||||
| SF-268 | CNS | 4.11 | >100 | >100 | |||||
| SF-295 | CNS | 5.81 | >100 | >100 | PC-3 | Prostate | 4.39 | >100 | >100 |
| SF-539 | CNS | 2.49 | >100 | >100 | DU-145 | Prostate | 2.51 | >100 | >100 |
| SNB-19 | CNS | >100 | >100 | >100 | |||||
| SNB-75 | CNS | 8.75 | >100 | >100 | NCI/ADR-RES | Breast | 3.56 | >100 | >100 |
| U251 | CNS | 13.7 | >100 | >100 | MDA-MB-231/ATCC | Breast | 24.4 | >100 | >100 |
| HS 578T | Breast | 14.2 | >100 | >100 | |||||
| MDA-MB-435 | Breast | 1.44 | >100 | >100 | |||||
| MDA-N | Breast | 1.78 | >100 | >100 | |||||
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| BT-549 | Breast | >100 | >100 | >100 |