The median GI50, TGI, and LC50 values obtained after treatment with cis-AVTP or 6-MP in different histotypes Values are given in micromolar concentration (μM). The number in parentheses is the rank order of a particular histotype after treatment with cis-AVTP or 6-MP.
GI50 | TGI | LC50 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| AVTP | 6-MP | AVTP | 6-MP | AVTP | 6-MP | ||||
| Leukemia | 0.19 (1) | 1.44 (1) | 52.5* (9) | >100 (1-9) | >100 (8-9) | >100 (1-9) | |||
| NSCL | 1.29 (7) | 3.89 (3) | 12.2 (8) | >100 (1-9) | 53.7 (6) | >100 (1-9) | |||
| Colon | 1.13 (6) | 4.76 (5) | 4.42 (4) | >100 (1-9) | 25.3 (3) | >100 (1-9) | |||
| CNS | 1.69 (9) | 7.28 (8) | 10.7 (7) | >100 (1-9) | 52.7 (5) | >100 (1-9) | |||
| Melanoma | 0.48 (2) | 4.82 (6) | 3.24 (2) | >100 (1-9) | 9.58 (1) | >100 (1-9) | |||
| Ovarian | 0.91 (5) | 5.30 (7) | 4.55 (5) | >100 (1-9) | 27.7 (4) | >100 (1-9) | |||
| Renal | 0.49 (3) | 4.74 (4) | 2.67 (1) | >100 (1-9) | 10.7 (2) | >100 (1-9) | |||
| Prostate | 1.69 (8) | 3.45 (2) | 7.09 (6) | >100 (1-9) | 54.8 (7) | >100 (1-9) | |||
| Breast | 0.55 (4) | 8.86 (9) | 3.98 (3) | >100 (1-9) | >100 (8-9) | >100 (1-9) | |||
↵* This median value is derived from three exact values below 100 μM and three values anywhere above 100 μM; this value may therefore be an underestimation