Metabolism of quinoline by P450 enzymes Values are mean rates ± the standard deviation of triplicate incubations. Rates are expressed in pmol product/nmol P450/min.
P450 | Quinoline N-oxide | 3-OH Quinoline | 5-OH Quinoline | 6-OH Quinoline | 8-OH Quinoline |
|---|---|---|---|---|---|
| 3A4 | 628 ± 80 | 30 ± 6 | 64 ± 10 | 45 ± 19 | 20 ± 2 |
| 2E1 | Trace | 845 ± 250 | 104 ± 6 | Trace | 221 ± 6 |
| 1A2 | 0 | 504 | 212 | 0 | 89 |
| 2A6 | 568 ± 16 | 98 ± 25 | 229 ± 34 | Trace | 9 ± 1 |
| 2B4 | 221 ± 32 | 2620 ± 792 | 85 | 34 | 88 |
| cam | 516 ± 9 | 0 | 1376 ± 42 | 0 | 0 |