Kinetic parameters for the sulfoxidation of phorate, disulfoton, sulprofos, and methiocarb by human liver microsomes
Km | Vmax | CLint | |
|---|---|---|---|
| μM | nmol/mg | μl/mg | |
| protein/min | protein/min | ||
| Phorate | 53.1 ± 2.4 | 7.21 ± 0.1 | 136 |
| Disulfoton | 36.6 ± 2.6 | 4.88 ± 0.1 | 130 |
| Sulprofos | 36.3 ± 3.3 | 0.74 ± 0.0 | 20 |
| Methiocarb | 45.1 ± 6.0 | 2.68 ± 0.2 | 59 |
Values are the mean ± S.E.M. (n = 3).