Pharmacokinetic parameters used in the prediction
Parameters | |
|---|---|
| Mean average steady-state verapamil concentrationa | 0.14 to 0.18 μM |
| R,S-Verapamil plasma concentration ratiob | 5 to 1 |
| (±)-Norverapamil/(±)-verapamil concentration ratioc | 1 |
| fu in plasmab | 11.0% (S-verapamil) |
| 6.40% (R-verapamil) | |
| 3.30% (Norverapamil) | |
| kdeg (min-1)d | 0.000769 to 0.00128 |