Comparison of the nucleotide and the deduced amino acid sequences of CYP3A4 with other CYP3A isoforms
To show genetic distance of CYP3A isoforms between human and experimental animal species, percentage of identities of respective CYP3A isoforms to human CYP3A4 were indicated. The isoforms were listed in the order of nucleotide identity to human CYP3A4. Since some isoforms have been isolated from mice, rats, guinea pigs, hamsters, and dogs, one isoform sharing the highest identity with human CYP3A4 of each animal species was shown.
Species | Forms | Identity | Accession No. | ||
|---|---|---|---|---|---|
| Nucleotide | Amino acid | ||||
| % | |||||
| Human | 3A4 | 100 | 100 | J04449 | |
| Cynomolgus monkey | 3A8 | 95.6 | 93.4 | S53047 | |
| Human | 3A7 | 94.2 | 88.3 | D00408 | |
| Marmoset | 3A21 | 93.5 | 89.5 | D31921 | |
| Human | 3A5 | 89.4 | 84.3 | J04813 | |
| Human | 3A43 | 84.5 | 75.7 | AC011904 | |
| Dog | 3A12 | 83.7 | 79.5 | X54915 | |
| Pig | 3A46 | 83.5 | 77.8 | AB052266 | |
| Pig | 3A29v1 | 82.8 | 76.5 | Z93099 | |
| Miniature pig | 3A29v5 | 82.5 | 75.3 | AF424780 | |
| Pig | 3A39 | 82.1 | 75.9 | AF109068 | |
| Sheep | 3A24 | 82.1 | 75.5 | U59378 | |
| Rabbit | 3A6 | 81.7 | 74.4 | J05034 | |
| Miniature pig | 3A22 | 81.5 | 75.0 | AB006010 | |
| Bovine | 3A28 | 81.3 | 73.0 | Y10214 | |
| Rat | 3A9 | 81.2 | 76.5 | U46118 | |
| Mouse | 3A13 | 81.2 | 75.5 | X63023 | |
| Goat | 3A19 | 81.2 | 75.2 | X76530 | |
| Guinea pig | 3A20 | 79.7 | 72.0 | D49731 | |
| Hamster | 3A31 | 78.2 | 69.2 | D86951 | |