TABLE 1

Characteristics of human liver donors


Liver Donor Identificationa

Age (yr)

Gender

Race

Diagnosis/Cause of Death
HL-N95 63 M Caucasian Cerebrovascular stroke
HL-N98 56 M Caucasian Head trauma
HL-N100 57 M Caucasian Metastatic renal cell carcinoma
HL-N131 10 M Caucasian Drowning
HL-N140 23 F Asian Head trauma
HL-N145 N.A. N.A. N.A. N.A.
HL-N147 13 F Hispanic Anoxia
HL-N148 43 M Caucasian Anoxia
HL-N154
3
F
Caucasian
Head trauma
  • N.A., data not available.

  • a Human hepatocytes from donors HL-N95, HL-N98, and HL-N100 were used to test all 14 compounds; donors HL-N131, HL-N140, HL-N145, HL-N147, and HL-N148 were used for concentration-response studies with CLZ, PB, PHN, and RIF; and donor HL-N154 was used for time-response studies with PB and RIF