Predicted in vivo clearance of PNU-96391 in humans by in vivo and in vitro data of rats, dogs, and monkeys
Species | Predicted CLblood in Humansa | Ratiob |
|---|---|---|
| l/h/kg | ||
| Rat | 0.39 ± 0.16 | 0.92 |
| Dog | 0.65 ± 0.26 | 1.5 |
| Monkey | 0.49 ± 0.20 | 1.2 |
| Human | 0.43 ± 0.16c | - |
-, not applicable.
↵ a Predicted value was calculated from the normalization method: (in vitro hepatic clearance in humans) × (in vivo clearance in animal species)/(in vitro hepatic clearance in animal species). Values are expressed as mean ± S.D. (n = 8)
↵ b Ratio of predicted CLblood to the observed value in humans (0.43 ± 0.16 l/h/kg)
↵ c The observed value obtained from the clinical studies (n = 39)