TABLE 3

Mean values ± S.D. of losartan MR in 126 healthy subjects with different genotypes of CYP2C9.

CYP2C9 Genotype
MR of Losartan
*1/*1 (n = 81) 0.91 ± 1.7
*1/*2 (n = 19) 1.2 ± 1.8
*2/*2 (n = 2) 0.49;3.4
*2/*3 (n = 2) 2.6;3.4
*1/*3 (n = 20) 2.3 ± 2.1a
*3/*3 (n = 2)
20;200a,b

  • ↵ a ***p < 0.001, compared with 2C9*1/*1

  • ↵ b **p < 0.01, when 2C9*3/*3 is compared with *1/*3, *2/*3, or *2/*2